Analysis Tools
mortality/aging
reproductive system
| N |
• XX gonads appear normal
|
|
• testes development is disrupted as confirmed by abnormal expression of the Sertoli cell marker Sox9
|
|
• some mice exhibit a reduction in the number or absence of testes cords and irregular morphology compared with wild-type mice
|
|
• in some mice
|
|
• cultured gonadal XY explants fail to form testis cords or express testis-specific markers but express ovarian markers unlike wild-type samples
• in XY gonads, proliferation of cells in the coelomic region is severely reduced compared to in wild-type mice
• in XY gonads, migration of mesonephric cells to form testes cords is impaired compared to in wild-type mice
|
|
• XY mice develop ovotestis that develop testes cords at the central portion while the poles are ovarian in appearance and marker expression
|
nervous system
spina bifida
(
J:153050
)
exencephaly
(
J:153050
)
homeostasis/metabolism
endocrine/exocrine glands
|
• testes development is disrupted as confirmed by abnormal expression of the Sertoli cell marker Sox9
|
|
• some mice exhibit a reduction in the number or absence of testes cords and irregular morphology compared with wild-type mice
|
|
• in some mice
|
embryo
spina bifida
(
J:153050
)
