Phenotypes Associated with This Genotype

Genotype
MGI:4361158

• Allelic Composition: Wnt2^{tm1.1(rtTA)Eem}/Wnt2^{tm1.1(rtTA)Eem}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:153098 )

• most mice die shortly after birth

respiratory system

abnormal lung vasculature morphology ( J:153098 )

• vascular endothelial plexus is dilated and dysfunctional

decreased mesenchymal cell proliferation involved in lung development ( J:153098 )

• mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice

abnormal lung-associated mesenchyme development ( J:153098 )

• however, lung branching of terminal airways is normal

• mice exhibit poor development of lung mesenchyme

pulmonary hypoplasia ( J:153098 )

• at E10.5 to E18.5, mice exhibit lung hypoplasia compared with wild-type mice

abnormal respiratory system physiology ( J:153098 )

• epithelial and mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice

homeostasis/metabolism

cyanosis ( J:153098 )

cardiovascular system

abnormal lung vasculature morphology ( J:153098 )

• vascular endothelial plexus is dilated and dysfunctional

cellular

decreased mesenchymal cell proliferation involved in lung development ( J:153098 )

• mesenchymal cell proliferation in the lungs is reduced compared with wild-type mice