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Phenotypes Associated with This Genotype
Genotype
MGI:4360918
Allelic
Composition		 Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Genetic
Background		 involves: 129 * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (5 available); any Casp1 mutation (41 available)
Casp4del mutation (5 available); any Casp4 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:50775 )
• freshly isolated peritoneal exudate cells (neutrophils and B cells) secrete less IL-1beta in response to LPS than in controls
• IL-1beta response to soluble FasL is similar to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory