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Phenotypes Associated with This Genotype
Genotype
MGI:4360796
Allelic
Composition
Tg(RBP3-ELOVL4*)1Kzh/0
Genetic
Background
C57BL/6-Tg(RBP3-ELOVL4*)1Kzh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• abnormalities are more evident as expression levels of the transgene increase in the three lines created
• mice exhibit localized regions of the retina that appear lighter because of depigmentation in areas of retinal pigment epithelium atrophy and photoreceptor degeneration
• at 18 months, 50% of photoreceptor in the outer nuclear layer are degenerated
• more severe in the center of the retina
• progressive, localized, and more severe in the center of the retina
• at rod-saturation, cone b-wave declines in amplitude compared to in wild-type mice
• at 84 weeks, rod b-wave amplitude is one-third of wild-type

nervous system
• at 18 months, 50% of photoreceptor in the outer nuclear layer are degenerated

pigmentation
• more severe in the center of the retina

Mouse Models of Human Disease
OMIM ID Ref(s)
Stargardt Disease 3; STGD3 600110 J:97173


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory