Phenotypes Associated with This Genotype

Genotype
MGI:4360658

• Allelic Composition: Grin2b^tm1Mim/Grin2b^tm1Mim
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:31622 )

• mice die shortly after birth without feeding; these mice can survive as long as P6 if hand-fed

behavior/neurological

absent gastric milk in neonates ( J:31622 )

• unless hand-fed, mice do not have milk in stomachs up to 6-7 hours after birth

absent suckling reflex ( J:31622 )

• sensory inputs do not induce the suckling response in mutant neonates

nervous system

disorganized barrel cortex ( J:31622 )

• no clear barrelettes are seen at P0 and at P2

• the terminal arbors of the primary sensory neurons in the barrelette regions have a diffuse distribution pattern and no distinct clustering is seen, whereas in control mice, terminal clusters coincide with barellettes

abnormal AMPA-mediated synaptic currents ( J:178913 )

• significant increase in mean mEPSC amplitudes

absence of NMDA-mediated synaptic currents ( J:31622 )

• in hippocampal CA1 slices, no NMDA component of EPSPs is detectable in mutant mice

absent long-term depression ( J:31622 )

• in hippocampal slices, no long lasting depression is observed in P2-P3 mutant mice