Phenotypes Associated with This Genotype

Genotype
MGI:4360520

• Allelic Composition: Hprt1^{tm2(CUX1)Anep}/Hprt1⁺
• Genetic Background: FVB.129P2-Hprt1^{tm2(CUX1)Anep}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

increased mammary adenocarcinoma incidence ( J:152682 )

♀

integument

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

increased mammary adenocarcinoma incidence ( J:152682 )

♀

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:152682 )

♀N • mice exhibit normal mammary gland development

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 53% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 20% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (56%), adenosquamous carcinomas (22%), adenomyoepithelioma (11%), and tubular/acinar adenoma (11%)

increased mammary adenocarcinoma incidence ( J:152682 )

♀