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Phenotypes Associated with This Genotype
Genotype
MGI:4360394
Allelic
Composition
Prom1tm1.1(DTA)Toko/Prom1tm1.1(DTA)Toko
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prom1tm1.1(DTA)Toko mutation (0 available); any Prom1 mutation (75 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice
• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice

growth/size/body
• tamoxifen treated mice exhibit reduced body weight compared with untreated and treated control mice

behavior/neurological
• tamoxifen treated mice exhibit walking abnormalities

cellular
• tamoxifen treated mice exhibit increased apoptosis in the granular layer of the cerebellum, cortex of telencephalon, white matter and midbrain unlike similarly treated and untreated control mice
• however, ventricular zone cells and their neurogenesis are normal in tamoxifen treated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory