Phenotypes Associated with This Genotype

Genotype
MGI:4360346

• Allelic Composition: Fyn^tm1Rmp/Fyn^tm1Rmp; Lck^tm1Mak/Lck^tm1Mak
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:37062 , J:37940 )

• thymus cellularity is 1-5% of normal (J:37062)

• thymic cellularity is 50- to 100-fold less than controls (J:37940)

decreased double-positive T cell number ( J:37940 )

• double-positive thymocytes are virtually absent

arrested T cell differentiation ( J:37062 , J:37940 )

• T cell development is blocked in the transition from double-negative to double-positive stage (J:37062)

• the thymocytes are predominately CD25⁺ and HAS^hi (J:37062)

• T cell development is arrested at the CD44^-CD25⁺ stage with 85-92% of thymocytes being at this stage (J:37940)

absent CD4-positive, alpha-beta T cells ( J:37940 )

• CD4 T cells are virtually absent from the periphery

absent CD8-positive, alpha-beta T cells ( J:37940 )

• CD8 T cells are virtually absent from the periphery

abnormal NK T cell number ( J:37940 )

• NK1.1⁺ alpha-beta T cells are virtually absent from the periphery

decreased gamma-delta intraepithelial T cell number ( J:112977 , J:37940 )

• CD8alpha-alpha gamma-delta IEL are present but in smaller numbers (J:112977)

• dendritic epithelial T cell numbers are severely reduced in the skin (J:37940)

absent T cells ( J:37062 )

• alpha-beta and gamma-delta T cells are absent in these mice

abnormal alpha-beta intraepithelial T cell morphology ( J:112977 )

• alpha-beta IEL are absent in these mice

• gamma-delta IEL are still present

hematopoietic system

thymus hypoplasia ( J:37062 , J:37940 )

• thymus cellularity is 1-5% of normal (J:37062)

• thymic cellularity is 50- to 100-fold less than controls (J:37940)

decreased double-positive T cell number ( J:37940 )

• double-positive thymocytes are virtually absent

arrested T cell differentiation ( J:37062 , J:37940 )

• T cell development is blocked in the transition from double-negative to double-positive stage (J:37062)

• the thymocytes are predominately CD25⁺ and HAS^hi (J:37062)

• T cell development is arrested at the CD44^-CD25⁺ stage with 85-92% of thymocytes being at this stage (J:37940)

absent CD4-positive, alpha-beta T cells ( J:37940 )

• CD4 T cells are virtually absent from the periphery

absent CD8-positive, alpha-beta T cells ( J:37940 )

• CD8 T cells are virtually absent from the periphery

abnormal NK T cell number ( J:37940 )

• NK1.1⁺ alpha-beta T cells are virtually absent from the periphery

decreased gamma-delta intraepithelial T cell number ( J:112977 , J:37940 )

• CD8alpha-alpha gamma-delta IEL are present but in smaller numbers (J:112977)

• dendritic epithelial T cell numbers are severely reduced in the skin (J:37940)

absent T cells ( J:37062 )

• alpha-beta and gamma-delta T cells are absent in these mice

abnormal alpha-beta intraepithelial T cell morphology ( J:112977 )

• alpha-beta IEL are absent in these mice

• gamma-delta IEL are still present

endocrine/exocrine glands

thymus hypoplasia ( J:37062 , J:37940 )

• thymus cellularity is 1-5% of normal (J:37062)

• thymic cellularity is 50- to 100-fold less than controls (J:37940)