About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4360189
Allelic
Composition		 Inpp5etm1.1Ssch/Inpp5etm1.2Ssch
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5etm1.1Ssch mutation (0 available); any Inpp5e mutation (31 available)
Inpp5etm1.2Ssch mutation (0 available); any Inpp5e mutation (31 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:152712 )
• mice display increased body weight after tamoxifen treatment
kidney cortex cyst ( J:152712 )
• glomerular cysts are seen in 6 month old tamoxifen treated mice

renal/urinary system
kidney cortex cyst ( J:152712 )
• glomerular cysts are seen in 6 month old tamoxifen treated mice

vision/eye
abnormal retina photoreceptor layer morphology ( J:152712 )
• after tamoxifen treatment the retinal photoreceptor layer is completely absent

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory