Analysis Tools
nervous system
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• young mice exhibit a loss of GABAergic interneurons compared to in wild-type mice
• however, older mice exhibit normal numbers of GABAergic interneurons
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• adult and old mice exhibit a 42% and 38% reduction, respectively, of spontaneous inhibitory postsynaptic current (sIPSC) frequencies in CA1 pyramidal cells compared to in wild-type mice
• however, sIPSC amplitudes are normal
• evoked inhibitory postsynaptic currents are smaller than in wild-type mice
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• adult and old mice exhibit a reduction in frequencies of miniature inhibitory postsynaptic currents (mIPSC) compared with wild-type mice
• however, mIPSC amplitudes are normal
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