Phenotypes Associated with This Genotype

Genotype
MGI:4359864

• Allelic Composition: Tg(Myh6-tTA)6Smbf/0; Tg(tetO-Mir208a)#Dzw/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged heart in Tg(tetO-Mir208a)#Dzw/0 Tg(Myh6-tTA)6Smbf/0 mice

cardiovascular system

abnormal myocardial fiber morphology ( J:152696 )

• cardiomyocytes are about 50% bigger than in controls

enlarged heart ( J:152696 )

• a dramatic increase in size is seen at 4 months of age

increased heart weight ( J:152696 )

• heart weight to body weight ratios are increased

cardiac hypertrophy ( J:152696 )

• chambers are enlarged and ventricle walls are thickened suggesting hypertrophic growth

abnormal heart left ventricle morphology ( J:152696 )

• left ventricle diameter is increased in diastole and systole

thick ventricular wall ( J:152696 )

cardiac interstitial fibrosis ( J:152696 )

decreased cardiac muscle contractility ( J:152696 )

• a decrease in fractional shortening is detected at 3 and 7 months of age

atrioventricular block ( J:152696 )

• about 30% of mice show second degree AV blocks, in which one or more of the electrical impulses from the atria failed to pass through the AV node to the ventricles

prolonged PR interval ( J:152696 )

• at 7 months of age, prolongation of the PR interval is seen indicating a first degree atrioventricular (AV) block

muscle

abnormal myocardial fiber morphology ( J:152696 )

• cardiomyocytes are about 50% bigger than in controls

decreased cardiac muscle contractility ( J:152696 )

• a decrease in fractional shortening is detected at 3 and 7 months of age

growth/size/body

enlarged heart ( J:152696 )

• a dramatic increase in size is seen at 4 months of age

increased heart weight ( J:152696 )

• heart weight to body weight ratios are increased

cardiac hypertrophy ( J:152696 )

• chambers are enlarged and ventricle walls are thickened suggesting hypertrophic growth

cellular

cardiac interstitial fibrosis ( J:152696 )