Phenotypes Associated with This Genotype

Genotype
MGI:4359660

• Allelic Composition: Themis^tm1.1Hko/Themis^tm1.1Hko
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 5-fold in the periphery

decreased single-positive T cell number ( J:152601 )

• single positive thymocyte numbers are dramatically reduced in these mice

• CD4-single positive numbers are reduced by about 60% and CD8-single positive numbers by 40%

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:152601 )

• CD4⁺ T cell numbers are reduced 10-fold in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:152601 )

• CD8⁺ T cell numbers are reduced 5-fold in the periphery

decreased single-positive T cell number ( J:152601 )

• single positive thymocyte numbers are dramatically reduced in these mice

• CD4-single positive numbers are reduced by about 60% and CD8-single positive numbers by 40%