About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4359617
Allelic
Composition
Ryr2tm1Slh/Ryr2+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1Slh mutation (0 available); any Ryr2 mutation (325 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atrial pacing using atrial burst results in increased ectopic beats and reentry compared to in similarly treated wild-type mice
• atria myocyte exhibit increased sarcoplasmic reticulum calcium ion leak compared with wild-type cells
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide

homeostasis/metabolism
• mice are more susceptible to pacing-induced atrial fibrillation compared with similarly treated wild-type mice
• however, the increased susceptibility to pacing-induced atrial fibrillation can be rescued by over-expression of Adcy3 inhibitory peptide


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory