Phenotypes Associated with This Genotype

Genotype
MGI:4359483

• Allelic Composition: Pdx1^tm1.1Stof/Pdx1⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduction in Ngn3+ pancreatic endocrine progenitor cells in Pdx1^tm1.1Stof/Pdx1⁺ and Pdx1^tm1.1Stof/Pdx1^tm1.1Stof mice

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:152582 )

• at E17.5, beta cells occupy less pancreatic area than in wild-type mice

pancreas hypoplasia ( J:152582 )

abnormal pancreatic endocrine progenitor cell physiology ( J:152582 )

• at E19.5, apoptosis of Ngn3+ endocrine progenitor cells is increased compared to in wild-type mice

• however, the number of Ngn3+ endocrine progenitor cells at E17.5 is normal

homeostasis/metabolism

decreased circulating insulin level ( J:152582 )

• unlike similarly treated wild-type mice, glucose-stimulated male mice fail to exhibit an increase in plasma insulin levels while female mice exhibit reduced fasting insulin levels

impaired glucose tolerance ( J:152582 )

• at 3 to 4 weeks, male mice are glucose intolerant unlike wild-type mice

• however, female mice exhibit normal glucose tolerance at 3 to 4 weeks of age