Phenotypes for Apoe Nceh1 MGI:4359427 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Nceh1^tm1Ishi/Nceh1^tm1Ishi
Genetic Background	B6.129-Nceh1^tm1Ishi Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (35 available); any Apoe mutation (164 available)
Nceh1^tm1Ishi mutation (1 available); any Nceh1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:152385 )

• free cholesterol levels are increased 1.5-fold and 1.3-fold for males and females, respectively, compared to in Apoe^tm1Unc homozygotes

• cholesterol esters are increased 2-fold and 1.3-fold in males and females, respectively, compared to in Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:152385 )

• atherosclerotic lesions are increased compared to in Apoe^tm1Unc homozygotes (2.2-fold for males and 2.3-fold in females at 17 weeks, 1.7-fold in males and 2.4-fold for females at 21 weeks)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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