Phenotypes Associated with This Genotype

Genotype
MGI:4359384

• Allelic Composition: Tg(Gpbar1)1Auw/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:152388 )

• when fed a high-fat diet, islets have higher insulin content than islets from similarly treated wild-type mice

increased circulating insulin level ( J:152388 )

• in response to an oral glucose load when fed a high-fat diet

increased oxygen consumption ( J:152388 )

• during the dark phase when fed a high-fat diet

decreased respiratory quotient ( J:152388 )

• decreased during the dark phase when fed a high-fat diet

improved glucose tolerance ( J:152388 )

• compared with wild-type mice when fed a high-fat diet

endocrine/exocrine glands

abnormal pancreatic islet size ( J:152388 )

• when fed a high-fat diet, pancreatic islet cells do not exhibit hypertrophy as in similarly treated wild-type mice

increased insulin secretion ( J:152388 )

• when fed a high-fat diet, islets have higher insulin content than islets from similarly treated wild-type mice

behavior/neurological

decreased locomotor activity ( J:152388 )

• during the beginning of the dark phase regardless of diet