Phenotypes Associated with This Genotype

Genotype
MGI:4359383

• Allelic Composition: Gpbar1^tm1.2Auw/Gpbar1^tm1.2Auw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:152388 )

• when fed a high-fat diet, mice fail to exhibit a reduction in circulating insulin levels when treated with INT-777 compared with similarly treated wild-type mice

impaired glucose tolerance ( J:152388 )

• when fed a high-fat diet

decreased physiological sensitivity to xenobiotic ( J:152388 )

• when fed a high-fat diet, mice fail to exhibit a reduction in circulating insulin levels when treated with INT-777 compared with similarly treated wild-type mice