Phenotypes Associated with This Genotype

Genotype
MGI:4359264

• Allelic Composition: pad/pad
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:64447 )

• mice are stillborn or die within hours of birth

craniofacial

decreased basicranium angle ( J:7101 )

• angle is reduced

• smaller angle does not allow forward tongue movement under primary palate, therefore obstructs shelf movement

small mandible ( J:7101 , J:64447 )

• reduced growth seen (J:7101)

• reduced lower jaw (J:64447)

small maxilla ( J:7101 )

• reduced growth seen

median cleft palate ( J:64447 )

• mice have a large median cleft palate

shortened head ( J:64447 )

skeleton

decreased basicranium angle ( J:7101 )

• angle is reduced

• smaller angle does not allow forward tongue movement under primary palate, therefore obstructs shelf movement

small mandible ( J:7101 , J:64447 )

• reduced growth seen (J:7101)

• reduced lower jaw (J:64447)

small maxilla ( J:7101 )

• reduced growth seen

abnormal rib morphology ( J:64447 )

• mice have numerous abnormalities

abnormal vertebral column morphology ( J:64447 )

• mice have numerous abnormalities

abnormal epiphyseal plate morphology ( J:7101 )

abnormal long bone epiphyseal plate proliferative zone ( J:7101 )

• transmission EM showed abnormal particle distribution and size on rough endoplasmic reticulum and cell membranes

chondrodystrophy ( J:7101 )

digestive/alimentary system

median cleft palate ( J:64447 )

• mice have a large median cleft palate

abnormal intestine morphology ( J:64447 )

• intestine length is less than 50% of normal

limbs/digits/tail

short limbs ( J:64447 )

• extreme shortening of extremities

growth/size/body

median cleft palate ( J:64447 )

• mice have a large median cleft palate

shortened head ( J:64447 )