Phenotypes Associated with This Genotype

Genotype
MGI:4359167

• Allelic Composition: Nr1h2^tm1Djm/Nr1h2^tm1Djm; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:122372 )

• a significant increase in cortical the Abeta1-40 plaque number is seen in mice at 32 weeks of age compared transgenic mice on a wild-type background

• plaques are also increased in size

• there is also a significant increase in Abeta1-42 plaque number at this age

homeostasis/metabolism

amyloid beta deposits ( J:122372 )

• a significant increase in cortical the Abeta1-40 plaque number is seen in mice at 32 weeks of age compared transgenic mice on a wild-type background

• plaques are also increased in size

• there is also a significant increase in Abeta1-42 plaque number at this age