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Phenotypes Associated with This Genotype
Genotype
MGI:4358899
Allelic
Composition		 Pla2g4atm1Jvb/Pla2g4a+
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g4atm1Jvb mutation (0 available); any Pla2g4a mutation (63 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:141084 )
N
• mice do not exhibit premature death as do Tg(PDGFB-APPSwInd)20Lms mice

behavior/neurological
behavior/neurological phenotype ( J:141084 )
N
• mice do not exhibit the hyperactivity observed in Tg(PDGFB-APPSwInd)20Lms mice
abnormal spatial learning ( J:141084 )
• mice exhibit a complete or partial recovery of the learning deficits observed in Tg(PDGFB-APPSwInd)20Lms mice with improved target crossing in a Morris water maze
decreased anxiety-related response ( J:141084 )
• mice exhibit disinhibition-like behaviors in an elevated plus maze compared with wild-type mice that are not as severe as in Tg(PDGFB-APPSwInd)20Lms mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory