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Phenotypes Associated with This Genotype
Genotype
MGI:4358870
Allelic
Composition		 Nr1h2tm1Djm/Nr1h2tm1Djm
Nr1h3tm1Djm/Nr1h3tm1Djm
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h2tm1Djm mutation (3 available); any Nr1h2 mutation (29 available)
Nr1h3tm1Djm mutation (3 available); any Nr1h3 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver cholesterol level ( J:64343 )
• hepatic cholesterol levels are 4-fold higher than controls in mice fed a 0.2% cholesterol diet

liver/biliary system
increased liver cholesterol level ( J:64343 )
• hepatic cholesterol levels are 4-fold higher than controls in mice fed a 0.2% cholesterol diet

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory