Phenotypes Associated with This Genotype

Genotype
MGI:4358789

• Allelic Composition: Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased blood osmolality ( J:114240 )

• during water deprivation, mice exhibit a greater increase in plasma osmolality compared with similarly treated wild-type mice

decreased urine osmolality ( J:114240 )

• at P320, urine osmolality is decreased compared to in wild-type mice

• after water deprivation, mice exhibit decreased urine osmolality compared with similarly treated wild-type mice

• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice

• however, water deprived mice respond normally to acute vasopressin treatment

abnormal response/metabolism to endogenous compounds ( J:114240 )

• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice

• however, water deprived mice respond normally to acute vasopressin treatment

growth/size/body

decreased body weight ( J:114240 )

• during water deprivation, mice exhibit a greater loss in basal body weight compared with similarly treated wild-type mice

renal/urinary system

decreased urine osmolality ( J:114240 )

• at P320, urine osmolality is decreased compared to in wild-type mice

• after water deprivation, mice exhibit decreased urine osmolality compared with similarly treated wild-type mice

• water deprived mice treated with vasopressin exhibit a decrease in urine osmolality compared with similarly treated wild-type mice

• however, water deprived mice respond normally to acute vasopressin treatment