Phenotypes Associated with This Genotype

Genotype
MGI:4358621

• Allelic Composition: Oprm1^tm1Jep/Oprm1^tm1Jep
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• however, analgesic response to U50,488H, naloxone benzoylhydrazone (NalBzoH), morphine-6beta-glucuronide (M6G), heroine, 6-acetyl-morphine, and D-Penicillamine(2,5)-enkephalin (DPDPE) is normal (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)

enhanced behavioral response to anesthetic ( J:65217 )

• improgan analgesic response is enhanced in female mice compared to in wild-type mice

• however, improgan analgesia in males is normal

impaired behavioral response to anesthetic ( J:52952 , J:65217 )

• in a tail flick assay, mice treated with morphine, methadone, or DAMGO display nearly no analgesic response unlike in similarly treated wild-type mice (J:52952)

• however, analgesic response to U50,488H, naloxone benzoylhydrazone (NalBzoH), morphine-6beta-glucuronide (M6G), heroine, 6-acetyl-morphine, and D-Penicillamine(2,5)-enkephalin (DPDPE) is normal (J:52952)

• morphine analgesic response is abolished unlike in wild-type mice (J:65217)