Phenotypes Associated with This Genotype

Genotype
MGI:4358597

• Allelic Composition: Tnfsf10^tm1Mjs/Tnfsf10^tm1Mjs
• Genetic Background: C.129-Tnfsf10^tm1Mjs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:87620 )

• mice have increased survivor rates 3 and 7 days after Listeria monocytogenes infection compared to controls

immune system

immune system phenotype ( J:84838 )

N • the defective negative selection of T cells observed in one study is not observed in this study

thymus hyperplasia ( J:82145 , J:84838 )

• mean thymic cellularity is increased about 10% at 6-7 weeks of age (J:82145)

• mean thymic cellularity is increased about 20% (J:84838)

abnormal negative T cell selection ( J:82145 )

• Background Sensitivity: negative selection mediated by mammary tumor virus-9 antigen is restricted to mice expressing I-E ( eg BALB/c) and does not occur in mice without I-E expression (C57BL/6)

• Background Sensitivity: Mtv(9)-induced negative selection of Vbeta3, Vbeta5, and Vbeta11 T cells is impaired in these mice compared to BALB/c controls

• Background Sensitivity: these T cells are functional as determined by beta-chain specific antibodies that induce cytokine secretion

impaired natural killer cell mediated cytotoxicity ( J:73948 )

• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells

• there is less NK-mediated tumor lysis when Renca tumor cells are inoculated into mutant mice

• this results in increased metastasis in liver especially at lower tumor cell doses

• similar results are seen with 4T1 tumor cells when they are injected into the mammary gland

liver inflammation ( J:87620 )

• mice are resistant to hepatitis induced by ConA administration

• mice fail to develop liver lesions though some inflammatory infiltrates are observed

• the number of apoptotic cells in the liver 24 hours after ConA injection is significantly reduced compared to controls

• hepatitis associated with Listeria infection is also much less severe compared to controls

decreased susceptibility to bacterial infection ( J:87620 )

• mice are resistant to Listeria monocytogenes infection

• CFU are 100-fold lower in the liver compared to controls 3 days after infection

• hepatitis associated with Listeria infection is much less severe compared to controls

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:87620 )

• mice have increased survivor rates 3 and 7 days after Listeria monocytogenes infection compared to controls

neoplasm

increased incidence of induced tumors ( J:73948 )

• mice are more prone to developing metastasis from inoculation of low numbers of 4T1 or Renca tumor target cells

increased incidence of tumors by chemical induction ( J:73948 )

• injection of the low dose (100 microgram) chemical carcinogen MCA leads to three times more fibrosarcomas that occur with an earlier incidence

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:73948 )

• injection of the low dose (100 microgram) chemical carcinogen MCA leads to three times more fibrosarcomas that occur with an earlier incidence

hematopoietic system

hematopoietic system phenotype ( J:84838 )

N • the defective negative selection of T cells observed in one study is not observed in this study

thymus hyperplasia ( J:82145 , J:84838 )

• mean thymic cellularity is increased about 10% at 6-7 weeks of age (J:82145)

• mean thymic cellularity is increased about 20% (J:84838)

abnormal negative T cell selection ( J:82145 )

• Background Sensitivity: negative selection mediated by mammary tumor virus-9 antigen is restricted to mice expressing I-E ( eg BALB/c) and does not occur in mice without I-E expression (C57BL/6)

• Background Sensitivity: Mtv(9)-induced negative selection of Vbeta3, Vbeta5, and Vbeta11 T cells is impaired in these mice compared to BALB/c controls

• Background Sensitivity: these T cells are functional as determined by beta-chain specific antibodies that induce cytokine secretion

impaired natural killer cell mediated cytotoxicity ( J:73948 )

• activated splenic and liver NK cells are less efficient in their killing of 4T1 or Renca tumor target cells

• there is less NK-mediated tumor lysis when Renca tumor cells are inoculated into mutant mice

• this results in increased metastasis in liver especially at lower tumor cell doses

• similar results are seen with 4T1 tumor cells when they are injected into the mammary gland

liver/biliary system

liver inflammation ( J:87620 )

• mice are resistant to hepatitis induced by ConA administration

• mice fail to develop liver lesions though some inflammatory infiltrates are observed

• the number of apoptotic cells in the liver 24 hours after ConA injection is significantly reduced compared to controls

• hepatitis associated with Listeria infection is also much less severe compared to controls

endocrine/exocrine glands

thymus hyperplasia ( J:82145 , J:84838 )

• mean thymic cellularity is increased about 10% at 6-7 weeks of age (J:82145)

• mean thymic cellularity is increased about 20% (J:84838)