Phenotypes Associated with This Genotype

Genotype
MGI:4358494

• Allelic Composition: Cacna2d2^du/Cacna2d2^du
• Genetic Background: involves: DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:116 )

• viability is reduced compared with normal littermates

behavior/neurological

abnormal gait ( J:116 )

• waddling gait appears after 14 days of age, is seldom apparent before 19 days of age, involves a hunched appearance and a toeing out of the hind feet, and as they age they develop a reeling gait with a tendency to fall to one side

reproductive system

reduced female fertility ( J:116 )

♀ • females rarely breed

reduced male fertility ( J:116 )

♂ • majority of homozygous males are poor breeders

growth/size/body

decreased body size ( J:116 )

• slightly smaller than normal littermates