Phenotypes Associated with This Genotype

Genotype
MGI:4358304

• Allelic Composition: Fabp7^tm1Owad/Fabp7^tm1Owad
• Genetic Background: B6.Cg-Fabp7^tm1Owad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced contextual conditioning behavior ( J:111540 )

• mice exhibit enhanced fear memory compared with wild-type mice

increased anxiety-related response ( J:111540 )

• in an elevated plus maze, mice spend less time on the open arms and more time in the closed arms compared with wild-type mice

induced hyperactivity ( J:128536 )

• following repeated treatment with MK-801

nervous system

abnormal hippocampus morphology ( J:128536 )

• the hippocampus contains 30% fewer proliferating cells than in wild-type mice

abnormal dentate gyrus morphology ( J:128536 )

• the dentate gyrus contains fewer astrocytes, neural stem cells, and early and late progenitor cells compared to in wild-type mice

reduced NMDA-mediated synaptic currents ( J:111540 )

• the amplitude of NMDA-mediated current induced by DHA (docosahexaenoic acid) are lower than in similarly treated wild-type mice

decreased prepulse inhibition ( J:128536 )

• prepulse inhibition and latency are decreased compared to in wild-type mice

homeostasis/metabolism

decreased fatty acids level ( J:111540 )

• brain docosahexaenoic acid levels are decreased 4% compared to in wild-type mice

abnormal response/metabolism to endogenous compounds ( J:111540 )

• the amplitude of NMDA-mediated current induced by DHA (docosahexaenoic acid) are lower than in similarly treated wild-type mice