Phenotypes Associated with This Genotype

Genotype
MGI:4358248

• Allelic Composition: Tg(Pbsn-ERG*)1Vv/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

endocrine/exocrine glands

abnormal prostate gland epithelium morphology ( J:131932 )

♂ • basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy

♂ • ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls

♂ • epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age

reproductive system

abnormal prostate gland epithelium morphology ( J:131932 )

♂ • basal cells are surrounded by abnormally accumulating luminal cells and become displaced away from the stromal cell compartment; direct contact between luminal cells and the basement membrane is observed by electron microscopy

♂ • ratio of basal cells to total prostate epithelial cells is significantly decreased compared to controls

♂ • epithelial compartment exhibits a small but significant increase in proportion of proliferating cells compared to controls

increased prostate intraepithelial neoplasia incidence ( J:131932 )

♂ • by 5-6 months of age, prostatic intraepithelial neoplasia (PIN) lesions are observed in ventral prostate; cells in these foci display epithelial nuclear pleomorphism and loss of polarization

♂ • number of lesions and cellular pleomorphism increase with mouse age; percentage of cells with nucleolomegaly increases with age