Phenotypes for Stk4 Tg(Lck-cre)#Zhu MGI:4358230 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Stk4^tm1.1Wtao/Stk4^tm1.2Wtao Tg(Lck-cre)#Zhu/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4^tm1.1Wtao mutation (0 available); any Stk4 mutation (75 available)
Stk4^tm1.2Wtao mutation (0 available); any Stk4 mutation (75 available)
Tg(Lck-cre)#Zhu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte number ( J:152323 )

decreased T cell number ( J:152323 )

• peripheral T cells

decreased CD4-positive, alpha-beta T cell number ( J:152323 )

• in the blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:152323 )

• in the blood, spleen, and lymph nodes

increased single-positive T cell number ( J:152323 )

• in the thymus

hematopoietic system

increased thymocyte number ( J:152323 )

decreased T cell number ( J:152323 )

• peripheral T cells

decreased CD4-positive, alpha-beta T cell number ( J:152323 )

• in the blood, spleen, and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:152323 )

• in the blood, spleen, and lymph nodes

increased single-positive T cell number ( J:152323 )

• in the thymus

endocrine/exocrine glands

increased thymocyte number ( J:152323 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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