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Phenotypes Associated with This Genotype
Genotype
MGI:4358213
Allelic
Composition		 Pax6tm2Pgr/Pax6+
Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy/0
Tg(Dct-cre)1Apdn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (93 available)
Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy mutation (0 available)
Tg(Dct-cre)1Apdn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal ciliary body morphology ( J:152253 )
• ciliary body varies from normal in appearance to reduced folding compared to Pax6 tm2Pgr/+; Tg(Dct-cre)1Apdn animals
abnormal iris morphology ( J:152253 )
• iris sphincter appearance is significantly, but variably improved compared to Pax6 tm2Pgr/+; Tg(Dct-cre)1Apdn
iris hypoplasia ( J:152253 )
• expression of transgenic Pax6 corrects iris length almost completely in Pax6tm2Pgr/+; Tg(Dct-cre)1Apdn animals (length is 92% of wild-type)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory