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Phenotypes Associated with This Genotype
Genotype
MGI:4358191
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic
Background		 B6.Cg-Apoetm1Unc Pik3cgtm1Dwu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Pik3cgtm1Dwu mutation (1 available); any Pik3cg mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:121582 )
• atherosclerotic lesions are reduced 52% at 35 weeks, 32% at 53 weeks, and 36% at 60 weeks compared to in Apoetm1Unc homozygotes

homeostasis/metabolism
decreased circulating cholesterol level ( J:121582 )
• total and non-HDL cholesterol after 60 weeks compared to in Apoetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory