Phenotypes Associated with This Genotype

Genotype
MGI:4358173

• Allelic Composition: Plcb2^tm1Dwu/Plcb2^tm1Dwu; Plcb3^tm1Dwu/Plcb3^tm1Dwu
• Genetic Background: involves: 129S1/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased platelet ATP level ( J:60348 )

• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells

decreased platelet calcium level ( J:60348 )

• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells

abnormal platelet physiology ( J:60348 )

• spreading of platelets on fibrinogen is impaired compared with wild-type cell

decreased platelet aggregation ( J:60348 )

• at low doses of ADP, thrombin, or collagen

decreased susceptibility to induced thrombosis ( J:60348 )

• following ferric chloride-induced arterial injury, mice fail to form arterial occlusions unlike in similarly treated wild-type mice

hematopoietic system

increased platelet ATP level ( J:60348 )

• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells

decreased platelet calcium level ( J:60348 )

• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells

abnormal platelet physiology ( J:60348 )

• spreading of platelets on fibrinogen is impaired compared with wild-type cell

decreased platelet aggregation ( J:60348 )

• at low doses of ADP, thrombin, or collagen

cellular

increased platelet ATP level ( J:60348 )

• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells