Phenotypes for Pik3cg MGI:4358172 MGI Mouse

increased susceptibility to induced morbidity/mortality ( J:131923 )

• at high viral titers of vaccinia virus, mice exhibit rapid weight loss, become ill, and die within 5 days unlike similarly treated wild-type mice

immune system phenotype ( J:131923 )

N	• naive CD8+ T cell migration, activation, proliferation, and differentiation are normal

decreased CD8-positive, alpha-beta T cell number ( J:131923 )

• fewer resident CD8+ T cells are detected in the peritoneum compared to in wild-type mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:131923 )

• CD8+ T cell migration in vitro in response to LTB4 and CCL5 is reduced compared with wild-type cells

• CD8+ T cell impaired migration in response to LTB4 is more severe than for CCL5

• however, migration in response to CCl21 is normal

abnormal response to infection ( J:131923 )

• following infection with VV-WR (vaccinia virus- Western Reserve strain), mice exhibit reduced influx of CD8+ T and NK cells into the peritoneum compared to in similarly treated wild-type mice

increased susceptibility to Poxviridae infection ( J:131923 )

• at high viral titers of vaccinia virus, mice exhibit rapid weight loss, become ill, and die within 5 days unlike similarly treated wild-type mice

decreased platelet calcium level ( J:107460 )

• thrombin-stimulated calcium mobilization in platelets is 25% less than in similarly treated wild-type cells

abnormal platelet physiology ( J:107460 )

• spreading of platelets on fibrinogen is impaired compared with wild-type cells

• however, platelet granule secretion is normal

decreased platelet aggregation ( J:107460 )

• when stimulated with low concentrations of ADP or collagen

decreased susceptibility to induced thrombosis ( J:107460 )

• following ferric chloride-induced arterial injury, mice fail to form arterial occlusions or form weak occlusions unlike in similarly treated wild-type mice