Phenotypes Associated with This Genotype

Genotype
MGI:4358151

• Allelic Composition: Pik3cg^tm1Dwu/Pik3cg^tm1Dwu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

decreased immunoglobulin level ( J:60348 )

• mice treated with NP-Ficoll produce fewer antibodies containing lambda light chain compared with similarly treated wild-type mice

cellular

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

hematopoietic system

impaired neutrophil chemotaxis ( J:60348 )

• in response to fMLP (formyl peptide N-formyl-Met-Leu-Phe) or MIP-1alpha (Ccl3), neutrophil migration is impaired in an in vitro migration assay compared with similarly treated wild-type cells

• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is impaired compared to in similarly treated wild-type mice

decreased immunoglobulin level ( J:60348 )

• mice treated with NP-Ficoll produce fewer antibodies containing lambda light chain compared with similarly treated wild-type mice