Phenotypes Associated with This Genotype

Genotype
MGI:4358108

• Allelic Composition: Fadd^tm1Wnt/Fadd^tm1Wnt; Tg(Fadd)33Wnt/0; Tg(Lck-cre)I57Jxm/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:69617 )

• reduced 2-fold

abnormal T cell differentiation ( J:69617 )

• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice

increased double-negative T cell number ( J:69617 )

• percent

decreased double-positive T cell number ( J:69617 )

• percent and absolute number

increased B cell number ( J:69617 )

• in the periphery

decreased CD4-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

hematopoietic system

thymus hypoplasia ( J:69617 )

• reduced 2-fold

abnormal T cell differentiation ( J:69617 )

• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice

increased double-negative T cell number ( J:69617 )

• percent

decreased double-positive T cell number ( J:69617 )

• percent and absolute number

increased B cell number ( J:69617 )

• in the periphery

decreased CD4-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

decreased CD8-positive, alpha-beta T cell number ( J:69617 )

• lower percentage in the periphery

endocrine/exocrine glands

thymus hypoplasia ( J:69617 )

• reduced 2-fold