Phenotypes Associated with This Genotype

Genotype
MGI:4358102

• Allelic Composition: Fadd^tm1Wnt/Fadd^tm1Wnt
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:46526 )

• mice die around E9.0

cellular

decreased sensitivity to induced cell death ( J:63946 )

• mouse embryonic fibroblasts stably transfected with TRAIL (Tnfsf10) receptors are resistant to TRAIL-mediated cell death unlike similarly treated wild-type cells

• however, retroviral expression of Fadd restores sensitivity to TRAIL cytotoxicity