Phenotypes Associated with This Genotype

Genotype
MGI:4357938

• Allelic Composition: Abl1^m1/Abl1^m1
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:148105 )

• calcium flux response to CD19 cross linking is absent

immune system

abnormal lymphopoiesis ( J:148105 )

• common lymphoid progenitors are dramatically reduced in number

decreased pro-B cell number ( J:148105 )

• "fraction A" pro-B-cells are dramatically reduced in number

abnormal B cell calcium ion homeostasis ( J:148105 )

• calcium flux response to CD19 cross linking is absent

hematopoietic system

abnormal lymphopoiesis ( J:148105 )

• common lymphoid progenitors are dramatically reduced in number

decreased pro-B cell number ( J:148105 )

• "fraction A" pro-B-cells are dramatically reduced in number

abnormal B cell calcium ion homeostasis ( J:148105 )

• calcium flux response to CD19 cross linking is absent

abnormal bone marrow cell physiology ( J:148105 )

• bone marrow cell response to Il7 is elevated