Phenotypes Associated with This Genotype

Genotype
MGI:4357935

• Allelic Composition: Abl1^m1/Abl1^m1
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal splenocyte physiology ( J:34903 )

• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers

• reduced spleen response to anti-IgM

abnormal immune system cell morphology ( J:34903 )

• response of peripheral blood cells to lipopolysaccharide is about 38% of control response

• response of peripheral blood cells to "conA" is reduced to about 18% of control response

abnormal B cell differentiation ( J:28795 )

• severe depletion becomes more common in mutants over 10 weeks of age

decreased pro-B cell number ( J:28795 )

• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age

• 77% of control levels overall

decreased mature B cell number ( J:28795 )

• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age

• levels reduced overall to 67% of controls

decreased pre-B cell number ( J:28795 )

• almost completely depleted in bone marrow at 2 months of age

• overall levels at 63% of controls

hematopoietic system

abnormal B cell differentiation ( J:28795 )

• severe depletion becomes more common in mutants over 10 weeks of age

decreased pro-B cell number ( J:28795 )

• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age

• 77% of control levels overall

decreased mature B cell number ( J:28795 )

• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age

• levels reduced overall to 67% of controls

decreased pre-B cell number ( J:28795 )

• almost completely depleted in bone marrow at 2 months of age

• overall levels at 63% of controls

abnormal bone marrow cell physiology ( J:28795 )

• bone marrow cell response to Il7 is elevated in young animals and reduced in older ones

abnormal splenocyte physiology ( J:34903 )

• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers

• reduced spleen response to anti-IgM