Analysis Tools
cellular
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• piRNAs are poorly expressed in developing spermatocytes
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• significant hypomethylation of germ cell-derived Line L1 and IAP sequences are found in testes compared to controls
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• spermatocytes have greatly increased levels of retrotransposon expression and activity that contribute to genomic instability
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reproductive system
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• piRNAs are poorly expressed in developing spermatocytes
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• significant hypomethylation of germ cell-derived Line L1 and IAP sequences are found in testes compared to controls
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• testis are 20% the weight of controls
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• during development, severe delays occur at the beginning of the meiotic prophase
• at P12, testes mostly contain spermatogonia with only 25% of tubes containing preleptotene spermatocytes
• at P14, testes display early pachytene germ cell loss with the most advanced germ cells being zygotene spermatocytes
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• the seminiferous tubules of 6-week-old mice have markedly reduced spermatocytes and no post-meiotic spermatids or spermatozoa
• male sterility is due to a zygotene:pachytene block during prophase-I
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• male mice are sterile
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endocrine/exocrine glands
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• testis are 20% the weight of controls
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