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Phenotypes Associated with This Genotype
Genotype
MGI:4356437
Allelic
Composition
Del(7Ipw-Snord116)1Jbro/+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the peak procedure task, when anticipating an event, mutants in which the allele is paternally inherited, start responding later than controls, and when terminating the behavior, mutants stop earlier, indicating that mutants use different strategies to time their behavior
• in the switch task test, mutants in which the allele is paternally inherited, enhance their performance by delaying the switching from one location to the other during the light phase, resulting in a reduction of the error rate and indicating altered risk assessment in decision making
• however, time perception is normal
• when the allele is inherited paternally, mice subjected to a timed food schedule in constant darkness significantly postpone their food anticipatory activity compared to controls
• overall food intake is increased in mice when the allele is inherited paternally

mortality/aging
• Background Sensitivity: when this allele is inherited paternally, 15% of mice die during the postnatal period unlike when the background includes FVB/N

cellular
• the maternal allele is imprinted and silenced

growth/size/body
• when this allele is inherited paternally but not maternally
• by P5 or P6 when this allele is inherited paternally

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Prader-Willi syndrome DOID:11983 OMIM:176270
J:242655


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory