Phenotypes Associated with This Genotype

Genotype
MGI:4356262

• Allelic Composition: Tg(PSEN1*L286V)1274Citr/0
• Genetic Background: B6.FVB-Tg(PSEN1*L286V)1274Citr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:151932 )

N • mice do not exhibit neurodegeneration

abnormal dendrite morphology ( J:151932 )

• spine density is increased 27% compared to in wild-type mice

• at 8 to 10 months, ramified spine density is decreased 33% compared to in wild-type mice

• however, spine density at 8 to 10 months is normal

enhanced NMDA-mediated synaptic currents ( J:151932 )

• at 4 to 5 months and at 8 to 10 months

reduced NMDA-mediated synaptic currents ( J:151932 )

• at 13 to 14 months

enhanced long-term potentiation ( J:151932 )

• at 4 to 5 months but not at 8 to 10 months

reduced long-term potentiation ( J:151932 )

• at 13 to 14 months