Phenotypes Associated with This Genotype

Genotype
MGI:4356106

• Allelic Composition: Pcdha^tm3Tyag/Pcdha^tm3Tyag
• Genetic Background: B6.Cg-Pcdha^tm3Tyag

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:151979 )

N • cortical barrel fields are structurally normal

abnormal substantia nigra morphology ( J:151979 )

• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice

abnormal globus pallidus morphology ( J:151979 )

• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice

abnormal dorsal striatum morphology ( J:151979 )

• the density of serotonergic fibers is decreased in the caudate putamen compared to in wild-type mice

abnormal thalamus morphology ( J:151979 )

• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice

abnormal lateral geniculate nucleus morphology ( J:151979 )

• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice

abnormal medial geniculate nucleus morphology ( J:151979 )

• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice

abnormal cingulate gyrus morphology ( J:151979 )

• mice exhibit decreased density of serotonergic fibers in the cingulate cortex compared with wild-type mice

abnormal entorhinal cortex morphology ( J:151979 )

• the density of serotonergic fibers are greater in the entorhinal cortex compared to in wild-type mice

abnormal hippocampus morphology ( J:151979 )

• serotonergic fibers are increased in the lacunosum-moleculare (184%) and the stratum radiatum (134%) of the CA1 region compared to in wild-type mice

• serotonergic fibers are decreased in the stratum oriens (44%) and dentage gyrus (21%) compared to in wild-type mice

abnormal dentate gyrus morphology ( J:151979 )

• serotonergic fibers are decreased 21% in the dentage gyrus compared to in wild-type mice

abnormal primary motor cortex morphology ( J:151979 )

• in the rostral part of the primary motor cortex, serotonergic fibers more densely innervated layer I and short, clumped fibers are frequently observed in layer II/III of only the most rostral part of the primary motor cortex compared to in wild-type mice

abnormal olfactory bulb morphology ( J:151979 )

• mice exhibit fewer serotonergic fibers in the layers encompassed by and including the external and internal plexiform layers compared to in wild-type mice

• mice exhibit more serotonergic fibers in the granule cell layer compared to in wild-type mice

abnormal serotonergic neuron morphology ( J:151979 )

• mice exhibit abnormal serotonergic fibers in the cerebral cortex, hippocampus, basal ganglia, and thalamus compared to in wild-type mice

behavior/neurological

increased grooming behavior ( J:151979 )

• resulting in lesions

growth/size/body

decreased body weight ( J:151979 )

• at 72 to 84 weeks

homeostasis/metabolism

increased serotonin level ( J:151979 )

• at 10 weeks, the level of serotonin is higher in the hippocampus compared to in wild-type mice

integument

skin lesions ( J:151979 )

• by 36 weeks, mice develop lesions on their head, neck, and snout unlike in wild-type mice