Phenotypes Associated with This Genotype

Genotype
MGI:4356080

• Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺; Tg(Gata1-cre)1Sho/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1 * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:151639 )

• mice die postnatally due to severe submucosal lymphedema of the small intestine

embryonic lethality during organogenesis, incomplete penetrance ( J:151639 )

• in 30% of mice die before E10.5

immune system

immune system phenotype ( J:151639 )

N • B cell development is normal with normal numbers of mature B cells

abnormal B cell differentiation ( J:151639 )

• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated

• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated

• however, fetal liver cell generated colonies are factor-dependent and not transformed

• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted

digestive/alimentary system

intestinal edema ( J:151639 )

• mice die postnatally due to severe submucosal lymphedema of the small intestine

growth/size/body

postnatal growth retardation ( J:151639 )

• mice fail to thrive

homeostasis/metabolism

intestinal edema ( J:151639 )

• mice die postnatally due to severe submucosal lymphedema of the small intestine

neoplasm

neoplasm ( J:151639 )

N • mice do not develop tumors

embryo

embryo phenotype ( J:151639 )

N • unlike in other mice lacking Etv6 expression, yolk vascular development is normal in mice that survive beyond E10.5

hematopoietic system

abnormal B cell differentiation ( J:151639 )

• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated

• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated

• however, fetal liver cell generated colonies are factor-dependent and not transformed

• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted