Phenotypes Associated with This Genotype

Genotype
MGI:4356058

• Allelic Composition: Cr2^tm1Hmo/Cr2^tm1Hmo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen

abnormal B cell activation ( J:151991 )

• B cells fail to react to sub-optimal doses of antigen coated in C3 complement

hematopoietic system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen

abnormal B cell activation ( J:151991 )

• B cells fail to react to sub-optimal doses of antigen coated in C3 complement