Phenotypes Associated with This Genotype

Genotype
MGI:4356057

• Allelic Composition: Cr2^{tm2.1(HLA-A)Crr}/Cr2^{tm2.1(HLA-A)Crr}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells have a decreased ability to produce antigen-specific antibodies to low doses of antigen

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have enhanced ability in class switch recombination in response to low dose antigen

hematopoietic system

abnormal memory B cell differentiation ( J:151991 )

• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen

abnormal B cell physiology ( J:151991 )

• B cells fail to internalize complement coated immune complexes

• bone marrow chimeric mice containing mutant B cells have a decreased ability to produce antigen-specific antibodies to low doses of antigen

abnormal class switch recombination ( J:151991 )

• bone marrow chimeric mice have enhanced ability in class switch recombination in response to low dose antigen