Phenotypes Associated with This Genotype

Genotype
MGI:4355949

• Allelic Composition: Ccl2^tm1Tyos/Ccl2^tm1Tyos
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal chemokine level ( J:151874 )

• in thioglycollate- or zymosan- induced peritonitis models, reduced level of Ccl2 and Ccl7 are detected in peritoneal fluid

abnormal chemokine secretion ( J:151874 )

• there is little Ccl2 (MCP-1) secretion by peritoneal macrophages activated in vitro compared to controls

• secretion of Ccl7 (MCP-3) is also dramatically reduced by these activated macrophages

homeostasis/metabolism

abnormal chemokine level ( J:151874 )

• in thioglycollate- or zymosan- induced peritonitis models, reduced level of Ccl2 and Ccl7 are detected in peritoneal fluid