Phenotypes Associated with This Genotype

Genotype
MGI:4355883

• Allelic Composition: Cd1d1^tm1.1Boes/Cd1d1^tm1.1Boes
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK T cell morphology ( J:151699 )

• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7

• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls

• these cells have increased expression of immature markers such as Slamf1 and CD69

• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls

decreased NK T cell number ( J:151699 )

• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen

abnormal NK T cell physiology ( J:151699 )

• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated

• IFN-gamma secretion upon activation is similar to controls

abnormal dendritic cell antigen presentation ( J:151699 )

• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells

decreased interleukin-2 secretion ( J:151699 )

• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated

abnormal interleukin-4 secretion ( J:151699 )

• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated

hematopoietic system

abnormal NK T cell morphology ( J:151699 )

• Valpha14 invariant NKT cell displaya bias in their Vbeta repertoire, with an overrepresentation of Vbeta7

• thymic Valpha14 invariant NKT cells significantly remain in the earlier stages of development compared to controls

• these cells have increased expression of immature markers such as Slamf1 and CD69

• thymic Valpha14 invariant NKT cells at all stages of development in the thymus display increased rates of apoptosis compared to controls

decreased NK T cell number ( J:151699 )

• Valpha14 invariant NKT cell numbers are reduced 60% in the thymus and 80% in the liver and spleen

abnormal NK T cell physiology ( J:151699 )

• Valpha14 invariant NKT cells have reduced expression of IL-2 and IL-4 when activated

• IFN-gamma secretion upon activation is similar to controls