Phenotypes for Msh2 Xpc MGI:4355517 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Msh2^tm1Rak/Msh2^tm1Rak Xpc^tm1Ecf/Xpc^tm1Ecf
Genetic Background	involves: 129P2/OlaHsd * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Rak mutation (0 available); any Msh2 mutation (95 available)
Xpc^tm1Ecf mutation (1 available); any Xpc mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:94447 )

• fewer epidermal cells accumulate in S-phase and in G2-phase after treatment with 500J/m² of UV radiation than in mice carrying Xpc^tm1Ecf alone

increased cellular sensitivity to ultraviolet irradiation induced cell death ( J:94447 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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