Phenotypes Associated with This Genotype

Genotype
MGI:4355231

• Allelic Composition: Apoe^{tm3(APOE*4)Mae}/Apoe^{tm3(APOE*4)Mae}; Ldlr^tm1(LDLR)Mae/Ldlr⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

amyloid beta deposits ( J:146721 )

• significant plaque development on a high fat diet relative to Apoe^{tm2(APOE*3)Mae} mice who show very little plaque development

abnormal circulating lipid level ( J:146721 )

• significantly lower lipid levels on a normal fat diet

increased circulating cholesterol level ( J:146721 )

• greater increase in total cholesterol when fed a high fat diet than seen in Apoe^{tm2(APOE*3)Mae} mice

• very high total cholesterol to triglyceride ratio on a high fat diet

• increased number of non-HDL particles

• plasma cholesterol decrease over time relative to mice lacking Ldlr^tm1(LDLR)Mae

increased circulating triglyceride level ( J:146721 )

• higher triglyceride levels in females on a normal fat diet

nervous system

amyloid beta deposits ( J:146721 )

• significant plaque development on a high fat diet relative to Apoe^{tm2(APOE*3)Mae} mice who show very little plaque development