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Phenotypes Associated with This Genotype
Genotype
MGI:4355226
Allelic
Composition		 Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Ldlrtm1(LDLR)Mae/Ldlr+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm2(APOE*3)Mae mutation (2 available); any Apoe mutation (164 available)
Ldlrtm1(LDLR)Mae mutation (2 available); any Ldlr mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloid beta deposits ( J:146721 )
• very little plaque development
abnormal circulating lipid level ( J:146721 )
• significantly lower lipid levels on a normal fat diet

nervous system
amyloid beta deposits ( J:146721 )
• very little plaque development

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory