Phenotypes Associated with This Genotype

Genotype
MGI:4355049

• Allelic Composition: Tg(Cd4-Dtx1)1Mzl/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:151605 )

• T cells produce less IL-2 after activation compared to controls

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

decreased interleukin-2 secretion ( J:151605 )

• thymocytes and T cells produce less IL-2 after activation relative to controls

hematopoietic system

abnormal T cell activation ( J:151605 )

• T cells produce less IL-2 after activation compared to controls

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

endocrine/exocrine glands

abnormal thymocyte activation ( J:151605 )

• thymocyte proliferation and IL-2 secretion after activation is reduced compared to controls

cellular

decreased T cell proliferation ( J:151605 )

• acitvation induced T cell proliferation is decreased relative to controls